Used in immunological research to modulate CD40 signaling, this antibody is instrumental in studying B cell activation, dendritic cell maturation, and T cell-dependent immune responses. It serves as a reference reagent for evaluating CD40-targeted therapies, including those for autoimmune diseases, transplant rejection, and cancer immunotherapy. The antibody can act as an antagonist or agonist depending on context and is used in vitro and in vivo to block or stimulate CD40 pathways, aiding in the development of biologics and assessing immune checkpoint modulation.