Used in the development of therapeutic agents targeting angiogenesis, particularly in oncology. This antibody modulates the TIE2 signaling pathway, which plays a key role in blood vessel formation and stability. It is utilized in research and drug development for cancer treatments, especially in combination with other anti-angiogenic or immunotherapeutic agents. Its application extends to studying vascular remodeling in tumors and improving delivery of therapeutics through normalization of tumor vasculature. Also serves as a reference in biosimilar or biobetter antibody development.