Used in targeted cancer therapies, particularly for solid tumors such as glioblastoma and melanoma. Binds specifically to TEM7R (PLXDC2), a receptor overexpressed in tumor vasculature and cancer cells, enabling precise delivery of therapeutic agents or imaging molecules. Supports antibody-drug conjugate (ADC) development and is utilized in preclinical research to inhibit tumor growth and angiogenesis. Also serves as a tool for detecting TEM7R expression in tumor tissues, aiding in diagnostic and prognostic evaluations.