Used in immunological research and clinical applications to modulate T-cell activity, particularly in the context of transplant immunology. It targets the alpha-beta T-cell receptor complex, enabling selective depletion of activated T-cells involved in graft rejection. This antibody has been investigated in clinical trials for preventing organ rejection, especially in kidney transplantation, offering a potential alternative to broad immunosuppressive drugs with fewer side effects. Its high specificity allows for targeted immune modulation, preserving overall immune function while reducing the risk of rejection. Also used as a reference standard in flow cytometry and immunoassays to evaluate T-cell receptor expression and function.