Used in research and diagnostic applications to detect polyubiquitinated proteins, this antibody helps study protein degradation pathways, particularly the ubiquitin-proteasome system. It is valuable in neuroscience for analyzing protein aggregation in neurodegenerative diseases like Alzheimer's and Parkinson's. Also employed in cancer research to monitor the regulation of oncoproteins and tumor suppressors subject to ubiquitin-mediated degradation. Supports immunoprecipitation, Western blotting, and immunohistochemistry techniques to track polyubiquitin chain formation and dynamics in cellular models.