Used in targeted cancer therapy, particularly for tumors involving dysregulated NOTCH signaling pathways. It binds to the NOTCH1 receptor, blocking its activation and downstream signaling, which can inhibit tumor growth in cancers such as T-cell acute lymphoblastic leukemia (T-ALL) and certain solid tumors. Employed primarily in research and clinical development to evaluate the therapeutic potential of NOTCH1 inhibition. Also serves as a reference standard in antibody development and comparative studies for oncology drug discovery.