Used in targeted cancer therapies, particularly for delivering cytotoxic agents to tumor-associated macrophages in solid tumors. Binds specifically to uPARAP (urokinase plasminogen activator receptor-associated protein) expressed on the surface of certain cancer cells and stromal cells within the tumor microenvironment. Enables imaging of tumor stroma and supports development of antibody-drug conjugates (ADCs) for precision treatment. Also applied in research to study endocytosis pathways and antigen presentation in macrophages. Shows potential in fibrosis-targeted therapy due to high expression in fibrotic tissues.