Anti-IL-6 / IFNb2 Reference Antibody (clazakizumab)
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Used in the treatment of autoimmune and inflammatory diseases, particularly rheumatoid arthritis. It works by specifically binding to and inhibiting interleukin-6 (IL-6), a key cytokine involved in driving inflammation, joint damage, and immune system dysregulation. By blocking IL-6 signaling, it helps reduce disease activity, slow progression of joint destruction, and improve physical function in patients. It is administered intravenously or subcutaneously and has been investigated in clinical trials for its efficacy and safety profile in moderate to severe cases where other treatments have failed. Can be used in combination with other therapies, such as methotrexate, to enhance treatment efficacy. Also explored for use in other IL-6-mediated conditions such as Castleman’s disease, lupus, and certain cancers.
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