This reference antibody is designed to mimic the binding properties of spesolimab, a monoclonal antibody targeting the IL-36 receptor (IL-1RL2). It is used in laboratory research for applications such as binding assays, neutralization studies, and evaluation of inflammatory pathways in generalized pustular psoriasis (GPP). By blocking IL-36 signaling, it helps in studying the reduction of pro-inflammatory cytokines. Intended for in vitro and preclinical research only; not for human therapeutic use or clinical administration.