Used in research and development of vaccines and therapeutic antibodies targeting the Omicron variant of SARS-CoV-2. The protein helps in studying immune response, neutralizing antibody efficacy, and virus-receptor interactions. Commonly applied in ELISA, Western blot, and surface plasmon resonance assays to evaluate binding affinity and inhibition. Also serves as an antigen for generating monoclonal and polyclonal antibodies specific to the mutated Spike RBD region.