Used in immunological research to study T cell activation and co-stimulatory signaling pathways. Helps in the development of cancer immunotherapies by modulating immune responses. Commonly employed in binding assays and protein-protein interaction studies involving immune receptors and ligands. Supports the evaluation of therapeutic antibodies targeting the 4-1BB pathway. Enables detection and quantification in ELISA and other immunoassays due to the Fc tag. Facilitates in vitro and in vivo studies of immune cell proliferation, survival, and cytokine production.