Mouse SFRP5, Tag Free is widely used in research settings to study the Wnt signaling pathway, which plays a critical role in embryonic development, tissue homeostasis, and cancer progression. It serves as a soluble modulator that binds to Wnt ligands or Frizzled receptors, helping to regulate pathway activity. Researchers use this protein in cell culture assays to investigate its role in metabolic diseases, including obesity and type 2 diabetes, due to its anti-inflammatory properties in adipose tissue. It is also employed in binding studies and functional assays to explore interactions with other components of the Wnt cascade. Its tag-free form allows for native-like behavior in experimental systems, making it ideal for structural and functional analysis without interference from purification tags.