Used in research and development of vaccines and diagnostic assays targeting the Monkeypox virus. The L1R protein, when expressed with a His tag, facilitates purification and detection, making it valuable for studying immune responses and evaluating potential antiviral therapies. It serves as an antigen in serological tests to detect virus-specific antibodies in patient samples, aiding in disease surveillance and diagnosis. Additionally, it supports structural and functional studies to understand viral entry mechanisms and support the design of targeted interventions.