Used in research and development of vaccines and diagnostic tools targeting the Monkeypox virus. The H3L protein, fused with a mouse Fc tag, serves as an antigen to study immune responses, enabling the evaluation of antibody production and T-cell activation in preclinical studies. It supports serological assays to detect virus-specific antibodies in patient samples, aiding in outbreak surveillance and immunity assessment. The mFc tag facilitates purification and detection in laboratory settings, making it valuable for high-throughput screening and immunogenicity studies.