Used in research and development of vaccines and antiviral therapies targeting the Monkeypox virus. The I1L protein, fused with an mFc tag, serves as a key antigen for generating immune responses in preclinical studies. It enables detection and purification through the Fc tag, facilitating studies on virus-host interactions, antibody production, and immune response evaluation. Commonly applied in ELISA, Western blot, and neutralization assays to assess vaccine efficacy and monitor immune activity in animal models. Supports diagnostic tool development and serological testing due to its high immunogenicity and stability.