Used in immunological research to study tetraspanin-enriched microdomains and their role in immune cell signaling. Facilitates protein-protein interaction studies due to the His tag, enabling easy purification and detection. Employed in ELISA, Western blotting, and pull-down assays to investigate CD37-associated pathways in lymphocytes. Supports development of monoclonal antibodies targeting CD37 for potential cancer immunotherapies, particularly in B-cell malignancies. Also used as a reference antigen in flow cytometry for cell surface marker profiling.