Used in cancer research and drug development, particularly in studies involving targeted therapies. Acts as a binding target for monoclonal antibodies and antibody-drug conjugates due to its high expression in various tumor types. Employed in immunoassays and protein interaction studies to evaluate binding affinity and specificity. Serves as a critical reagent in the development of diagnostics and therapeutic agents for cancers including breast, lung, and pancreatic carcinomas. Its Fc tag enables easy detection and purification, and supports effector function assays in immunological applications.