The recombinant Human Transferrin Receptor (CD71) with His-Tag is widely used in research on iron metabolism, cellular uptake, and endocytosis mechanisms, as it binds iron-loaded transferrin to facilitate transport into cells. Due to CD71 overexpression on rapidly proliferating cells, including cancer cells, it is essential for developing targeted cancer therapies, such as antibody-drug conjugates, nanoparticles, and ligands specific to CD71. Employed in diagnostic applications, including immunoassays like ELISA and Western blot, to validate antibodies and study receptor expression. Supports structural biology, binding studies, and cell proliferation research. The His-Tag enables easy purification, immobilization, and detection in recombinant protein workflows, aiding the development of biologics and biosimilars.