Used in cancer research for studying trophoblast glycoprotein (TPBG) interactions, particularly in immunotherapy development. The Fc tag enables easy detection and purification, making it valuable in binding assays and antibody screening. Commonly applied in immuno-oncology studies to evaluate target engagement and immune cell activation. Also utilized in ELISA, flow cytometry, and protein-protein interaction experiments due to its detectable Fc region. Supports development of monoclonal antibodies and CAR-T cell therapies targeting solid tumors.