Used in research and development for studying angiogenesis, the process of new blood vessel formation, which plays a critical role in cancer progression and metastasis. This protein is instrumental in assays evaluating the efficacy of anti-angiogenic drugs, particularly those targeting the VEGF signaling pathway. Commonly employed in ELISA, surface plasmon resonance (SPR), and binding studies to measure interactions with VEGF ligands or therapeutic antibodies. Also utilized in high-throughput screening platforms to identify potential inhibitors of receptor activation. Its His tag facilitates easy purification and detection, making it valuable in recombinant protein workflows and immunoassay development.