Used in research and development of targeted cancer therapies, particularly in studies involving angiogenesis inhibition. Plays a key role in binding assays and high-throughput screening to identify potential inhibitors of vascular endothelial growth factor signaling. Commonly applied in immunoassays and protein-protein interaction studies due to the His tag facilitating purification and detection. Supports the development of monoclonal antibodies and small molecule drugs aimed at blocking tumor blood vessel formation. Also utilized in structural studies to understand receptor-ligand interactions and guide rational drug design.