Used in immunological research to study tetraspanin family protein interactions, particularly in immune cell signaling and membrane organization. The Fc tag enables easy detection and purification, making it valuable in immunoassays, protein-protein interaction studies, and antibody binding experiments. Commonly applied in flow cytometry, ELISA, and Western blotting to investigate CD37-associated pathways in lymphocytes and potential roles in autoimmune diseases and cancer immunotherapy.