Used in research and drug development for studying neurotrophic signaling pathways involved in neuronal survival, differentiation, and synaptic plasticity. Serves as a target protein for screening and characterizing small molecule inhibitors or therapeutic antibodies, particularly in cancers driven by NTRK3 fusions. The His tag facilitates purification and detection in biochemical assays, making it valuable in high-throughput drug discovery and mechanistic studies of TRK receptor activation and inhibition.