Used in immunological research to study the role of TREM1 (Triggering Receptor Expressed on Myeloid cells 1) in inflammation and immune responses. Facilitates the development of therapeutic strategies targeting excessive inflammatory reactions, such as those seen in sepsis, rheumatoid arthritis, and inflammatory bowel disease. The His Tag allows for easy purification and detection in experimental settings, making it valuable in protein-protein interaction studies and antibody development. Also employed in ELISA and surface plasmon resonance assays to screen potential inhibitors of TREM1 signaling.