The Human Transferrin Receptor (CD71), fused with an Fc tag, is a recombinant protein essential for research in iron metabolism and cellular uptake mechanisms. CD71 is overexpressed on the surface of rapidly proliferating cells, including many cancer cells, serving as a key target for therapeutic interventions. This reagent enables studies on receptor-ligand interactions, particularly with transferrin, via receptor-mediated endocytosis. It is utilized in the development of anti-CD71 antibodies, antibody-drug conjugates, and nanocarriers to enhance specificity and minimize off-target effects in cancer therapy. Additionally, it supports diagnostic tools for imaging and detecting CD71-expressing tumor cells, as well as investigations into cell proliferation, iron homeostasis, and related pathways.