Used in immunotherapy research, particularly in the development of treatments for multiple myeloma and other B-cell malignancies. Plays a key role in studying B-cell maturation and survival pathways. Serves as a target for monoclonal antibodies, bispecific T-cell engagers (BiTEs), and chimeric antigen receptor (CAR) T-cell therapies. The His tag facilitates purification and detection in experimental settings, making it valuable in assay development and drug screening.