Used in research to study B cell survival and activation, particularly in autoimmune diseases and B cell malignancies. The Fc tag enables easy detection and purification, making it valuable in immunoassays and protein interaction studies. Also employed in therapeutic development targeting BAFF signaling pathways, such as in lupus and rheumatoid arthritis. Binds specifically to BAFF (BLyS), helping block excessive B cell stimulation in preclinical models. Useful in ELISA, flow cytometry, and as a neutralizing agent in cell culture systems.