Used in research and development of cancer therapeutics due to its role in apoptosis signaling. Binds to TRAIL (TNF-related apoptosis-inducing ligand), making it valuable for studying tumor cell death pathways. Employed in protein-protein interaction assays, ELISA, and as a detection tool in flow cytometry when fused with Fc tags. Supports the development of biologics and monoclonal antibodies targeting death receptors for immunotherapy. Also used in structural studies to understand receptor-ligand binding and design of agonist antibodies for enhanced anti-tumor activity.