Used in research to study the biological role of TMEFF2, a transmembrane protein involved in cell signaling and regulation. The Fc tag allows for easy detection and purification, making it valuable in immunoassays and protein interaction studies. Commonly applied in cancer research, particularly in prostate and brain cancers, where TMEFF2 expression is altered. Also used to develop and test therapeutic antibodies and diagnostic tools due to its stable expression and detectable tag.