Used in immunological research to study tumor angiogenesis and stromal cell interactions. Serves as a capture or detection antigen in ELISA and other immunoassays for antibody screening. Employed in protein-protein interaction studies, particularly in cancer and inflammatory disease models. The His tag allows for easy purification and immobilization on nickel-based surfaces. Supports development of monoclonal antibodies targeting tumor-associated pericytes and cancer stroma. Also utilized in structural studies and epitope mapping due to its recombinant nature and tag-based detection.