Used in cancer research and drug development due to its role in tumor angiogenesis and stromal cell targeting. Binds to endothelial and pericyte cells in tumor tissues, making it a valuable tool for studying tumor microenvironment interactions. Employed in immunoassays and flow cytometry to detect and quantify TEM1 expression in cell populations. Supports the development of targeted therapies, including antibody-drug conjugates and diagnostic imaging agents. The Fc tag enables easy detection and purification, and enhances stability in biological assays. Investigated for use in fibrotic disease research due to expression in activated fibroblasts.