Used as a recombinant protein in research to study Wnt signaling pathway regulation. Plays a role in metabolic and inflammatory disease studies, particularly in insulin resistance and type 2 diabetes. Commonly applied in cell culture assays and protein-protein interaction experiments to investigate its antagonistic effect on Wnt proteins. Also utilized in ELISA, western blotting, and receptor binding studies to assess biological activity and antibody detection. Valuable in biomarker research and therapeutic development for obesity-related conditions.