Used in immunological research to study signal regulatory protein alpha (SIRPa) interactions with its ligand CD47, which plays a critical role in immune checkpoint pathways. The Fc tag enables easy detection and purification, making it valuable in binding assays, protein-protein interaction studies, and therapeutic development targeting the SIRPa-CD47 axis. Commonly applied in cancer immunotherapy research to modulate macrophage activity and enhance tumor cell phagocytosis. Also utilized in ELISA, flow cytometry, and surface plasmon resonance (SPR) to measure binding kinetics and screen potential inhibitors.