Used in immunological research to study myeloid cell signaling and immune regulation. Serves as a target antigen in the development of monoclonal antibodies for acute myeloid leukemia (AML) therapies. Employed in protein-protein interaction studies due to its role in cell surface receptor binding. The His tag facilitates purification and detection in recombinant protein assays. Applied in flow cytometry and ELISA for immune cell profiling and biomarker validation.