Used in immunological research to study signal regulatory protein alpha (SIRPa) interactions, particularly its binding to CD47, which plays a key role in immune checkpoint pathways. Facilitates the development of cancer immunotherapies by enabling in vitro assays to screen and characterize therapeutic antibodies or small molecules targeting the SIRPa-CD47 axis. The His Tag allows for easy detection and purification in experimental setups. Commonly used in ELISA, surface plasmon resonance (SPR), and protein-protein interaction studies.