Used in immunological research to study signal transduction in myeloid cells. Plays a role in understanding immune cell interactions, particularly in macrophage and dendritic cell regulation. Applied in protein-protein interaction assays, including binding studies with CD47. The His Tag facilitates purification and detection in recombinant expression systems. Commonly used in ELISA, surface plasmon resonance, and flow cytometry to analyze receptor-ligand binding and immune checkpoint pathways.