Used in immunological research to study eosinophil and mast cell regulation, particularly in asthma and allergic diseases. Binds specifically to Siglec-8 ligands on immune cells, enabling investigation of cell signaling, apoptosis, and inhibition of inflammatory responses. Commonly used in ELISA, flow cytometry, and receptor-ligand interaction studies. Supports development of biologics targeting eosinophilic disorders due to its role in modulating immune cell activity.