Used in immunological research to study the role of Siglec-3 (CD33) in immune regulation, particularly in myeloid cells. The Fc tag enables detection, purification, and binding assays, making it valuable in developing therapies for diseases like acute myeloid leukemia (AML), where CD33 is a therapeutic target. It is also employed in flow cytometry, ELISA, and protein-protein interaction studies to investigate immune receptor signaling and ligand binding.