Used in immunological research to study the role of Siglec-15 in immune regulation, particularly in macrophage and osteoclast function. Serves as a binding partner in protein-protein interaction assays and supports the development of therapeutics targeting immune checkpoints. Commonly applied in ELISA, flow cytometry, and surface plasmon resonance due to the Fc tag enabling easy detection and immobilization. Investigated for its potential in cancer immunotherapy and bone-related diseases.