Used as a target antigen in immunological research and drug development for ROR1-expressing cancers, such as chronic lymphocytic leukemia (CLL) and breast cancer, where ROR1 is highly expressed in tumor cells but minimally in normal cells, making it an attractive specific therapeutic target.

The Human ROR1, Fc Tag protein serves as an antigen for developing and validating ROR1-specific monoclonal antibodies, studying protein-protein interactions, and evaluating inhibitors of ROR1 function.

Additionally, it is employed in bioassays like ELISA and flow cytometry to precisely assess antibody or ligand binding to ROR1. The Fc tag facilitates easy detection and purification via interaction with Protein A or G.

Supports the development of CAR-T cell therapies and therapeutic antibodies by enabling functional and binding studies of ROR1 as a target antigen.