Used in research to study the role of ROR2 receptor in developmental signaling pathways, particularly in Wnt signaling. Helps in understanding skeletal development and diseases like brachydactyly and Robinow syndrome. Employed in protein-protein interaction studies and immunoassays due to the Fc tag, which allows detection and purification using anti-Fc antibodies. Supports drug discovery efforts targeting ROR2-related cancers and bone disorders.