Used in immunological research to study cell surface receptor interactions, particularly in immune modulation and inflammation pathways. The Fc tag enables easy detection and purification, making it valuable in binding assays and protein-protein interaction studies. Commonly applied in ELISA, flow cytometry, and immunoprecipitation experiments to investigate its role in cellular signaling and potential therapeutic targets. Also utilized in developing assays for drug screening where PTGFRN pathway involvement is suspected.