Used in research and diagnostic applications to study cell adhesion processes, particularly in inflammation and thrombosis. Binds to ligands like PSGL-1 on leukocytes, enabling analysis of leukocyte rolling and endothelial interactions. Employed in ELISA, flow cytometry, and protein-protein interaction studies. The His tag allows for easy purification and detection, making it valuable in immunoassays and therapeutic development targeting inflammatory diseases.