Used in research to study NOTCH3 signaling pathway involved in cell differentiation and development. Helps in understanding diseases like CADASIL, a genetic disorder causing stroke and dementia. The Fc tag enables easy detection and purification, making it valuable in immunoassays and protein interaction studies. Commonly used in ELISA, Western blot, and flow cytometry applications. Supports drug development by serving as a target for therapeutic antibodies and inhibitors.