Used in immunological research to study the role of Macrophage Migration Inhibitory Factor (MIF) in inflammatory responses and autoimmune diseases. The Fc tag enables easy detection and purification, making it valuable in immunoassays and protein interaction studies. Commonly applied in ELISA, Western blotting, and flow cytometry to investigate MIF-mediated signaling pathways. Also utilized in therapeutic development for targeting MIF in conditions like sepsis, rheumatoid arthritis, and atherosclerosis.