Used in research and development of targeted cancer therapies, particularly in studies involving tumor cell migration, invasion, and metastasis. Plays a role in immunological assays and binding studies to evaluate interactions with ligands or potential therapeutic antibodies. Commonly applied in protein-protein interaction experiments and as a control antigen in ELISA, surface plasmon resonance (SPR), and flow cytometry. The His Tag facilitates easy purification and detection, making it suitable for high-throughput screening and structural analysis.