Used in immunological research to study macrophage function and endocytic pathways. Serves as a detection tool in binding assays due to its specific interaction with ligands like advanced glycation end-products (AGEs) and pathogens. Employed in protein purification and immunoassay development thanks to the Fc tag, which allows for easy capture by Protein A/G resins and detection via anti-Fc antibodies. Also utilized in structural and functional studies of scavenger receptors involved in innate immunity and tissue homeostasis.