Used in immunological research to study the interaction between MICA and its receptor NKG2D, which plays a critical role in immune surveillance. The Fc tag allows for easy detection and purification, and facilitates binding studies in ELISA, flow cytometry, and surface plasmon resonance. Commonly employed in developing and evaluating therapeutic antibodies and immune checkpoint inhibitors. Also used to investigate tumor immune evasion mechanisms and to support the design of cancer immunotherapies.