Used in research to study integrin-mediated cell signaling, particularly in processes involving tissue fibrosis, wound healing, and cancer progression. The Fc tag enables easy detection and purification, making it valuable in immunoassays and protein interaction studies. It is also employed in therapeutic development targeting αvβ6 integrin, which plays a role in epithelial cell function and disease pathways such as pulmonary fibrosis and metastatic cancer. Its tagged form supports high-throughput screening of inhibitors and antibody-based drug candidates.