Used in immunological research to study immune checkpoint pathways, particularly in modulating T-cell and myeloid cell activity. Plays a role in understanding immune tolerance and evasion mechanisms, especially in cancer and autoimmune diseases. Commonly employed in protein-protein interaction studies, binding assays, and structural analysis due to the His tag facilitating purification and detection. Also utilized in developing therapeutic antibodies and evaluating drug candidates targeting the LILRB2 pathway.